Campo Grande is a fairly new town and an important transportation hub for the region. When Mato Grosso state was split in two in the '70s, Campo Grande became the capital of Mato Grosso do Sul. The Pantanal in Mato Grosso do Sul is less wild, more given over to cattle ranching, and significantly harder to access than in the north. That said, the avian life is still remarkable, and the lodges are larger, more established, and more luxurious by far.
As in the north, a stay in a Pantanal lodge normally involves a number of activities -- a boat trip to spot birds and caiman, a horseback trip through the fields, bird spotting by foot or in an open vehicle, and often a nighttime excursion to see nocturnal animals. Some lodges offer additional activities such as canoe trips, fishing expeditions, or specialized bird-watching outings. If you have a specialized interest, it's a good idea to make contact ahead of time.
The only roads around the Pantanal skirt the edges of the flood plain. From Campo Grande to Corumbá the BR-262 follows the southern border of the Pantanal, affording small inroads here and there, particularly around Miranda, Aquidauana, and towards Corumbá. However, with many of the more isolated lodges, such as the Fazenda Rio Negro and the Fazenda Alto Barranco, the only way in during many of the wetter months is by airplane. A three-passenger plane from Aquidauana will charge about R$1,190 (US$500) to make the 30-minute flight (the pilot charges for an hour of flying time, because he has to return empty). The round-trip flight cost is thus around R$2,380 (US$1,000) for three people. This extra cost should be factored in.