Given its status as a vacation getaway, Isla de Margarita has plenty of bars and nightclubs. Still, many visitors stick to their all-inclusive resort, which usually features a small collection of bars and a dance club and nightly entertainment revue. Others like to barhop sections of Avenida 4 de Mayo and Avenida Santiago Mariño.
By far the hippest and most happening scene can be found at Kamy Beach (tel. 0295/267-1185), located on Playa Varadero, just outside Pampatar. For a similar vibe, you can try Beach Bar (tel. 0295/267-2392), on Calle El Cristo in the La Caranta section of Pampatar.
If you're looking for something somewhat familiar, Señor Frogs (tel. 0295/262-0451), the popular Mexican chain, has a lively restaurant and bar in the Centro Comercial Costa Azul, near the Hilton, which turns into a raging dance club most evenings after 11pm. While over in the Sambil Mall, there's a local branch of the Hard Rock Café (tel. 0295/260-2400).
For a mellower scene, with a lot more atmosphere, I recommend both Guayoyo Café (tel. 0295/262-4514) and Mykonis Lounge (tel. 0295/267-1850), two side-by-side joints set on a steep cliff overlooking the ocean in Pampatar.
Casino gaming is an option on Margarita, with modern and well-fitted casinos at the Margarita Hilton, Laguna Mar, and Marina Bay hotels. The casino at the Hilton, by far, is the swankiest and most popular.