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The long, narrow bar is the most minimally appointed one that you’ll find on this stretch of Fremont Street, but that is by design. Cocktails take center stage here, made by a team of talented mixologists who use seasonal, artisanal, and house-made ingredients for well-executed tipples that focus on balance and flavor. Be prepared for the use of lots of bitters and stuff like Falernum and amaro in some pretty mind-blowing drinks. These folks can do more than just sling a gin and tonic or pour you a beer (though they do have an excellent craft selection, too). On weekends, house and techno DJs liven things up. Vanguard is open Monday through Friday from 4pm until 2am, and Saturday from 6pm until 2am.