Among the early inhabitants of Italy, the most significant were the Etruscans -- but who were they? No one knows, and the many inscriptions they left behind (mostly on graves) are of no help, since the Etruscan language has never been deciphered by modern scholars. It's thought they arrived on the eastern coast of Umbria several centuries before Rome was built, around 800 B.C. Their religious rites and architecture show an obvious contact with Mesopotamia; the Etruscans might have been refugees from Asia Minor who traveled westward about 1200 to 1000 B.C. Within 2 centuries, they had subjugated Tuscany and Campania and the Villanova tribes who lived there.
While the Etruscans built temples at Tarquinia and Caere (present-day Cerveteri), the few nervous Latin tribes that remained outside their sway gravitated to Rome, then little more than a sheepherding village. As its power grew, however, Rome increasingly profited from the strategically important Tiber crossing where the ancient Salt Way (Via Salaria) turned northeastward toward the central Apennines.
From their base at Rome, the Latins remained free of the Etruscans until about 600 B.C. But the Etruscan advance was inexorable, and though the tribes concentrated their forces at Rome for a last stand, they were swept away by the sophisticated conquerors. The new overlords introduced gold tableware and jewelry, bronze urns and terra-cotta statuary, and the best of Greek and Asia Minor art and culture; they also made Rome the governmental seat of all Latium. Roma is an Etruscan name, and the kings of Rome had Etruscan names: Numa, Ancus, Tarquinius, and even Romulus.
Under the combined influences of the Greeks and the Mesopotamian east, Rome grew enormously. A new port was opened at Ostia, near the mouth of the Tiber. Artists from Greece carved statues of Roman gods to resemble Greek divinities. From this enforced (and not always peaceable) mixture of Latin tribes and Etruscans grew the roots of what eventually became the Republic of Rome.
The Etruscans ruled until the Roman revolt around 510 B.C., and by 250 B.C., the Romans and their Campania allies had vanquished the Etruscans, wiping out their language and religion. However, many of the former rulers' manners and beliefs remained, assimilated into the culture. Even today, certain Etruscan customs and bloodlines are believed to exist in Italy, especially in Tuscany.
The best places to see the legacy left by these mysterious people are in Cerveteri and Tarquinia, outside Rome. Especially interesting is the Etruscan necropolis, just 6.5km (4 miles) southeast of Tarquinia, where thousands of tombs have been discovered. To learn more about the Etruscans, visit the National Etruscan Museum (Museo Nazionale di Villa Giulia) in Rome itself.