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This exquisite boutique hotel, located in the heart of Imperial Rome, set in a 20th century Palazzo, offers a unique lodging experience. With sweeping vistas from the roof terrace (the hotel’s top perk; you eat breakfast up here), elegant design and up-scale ambiance, guests are welcome as they would in any Roman home. The rooms, too, are magnificent: light-filled, spacious, sharp and modern, with cherrywood furniture, touches of glass and chrome to accent, unusually comfy beds, marble bathrooms, and plenty of cupboard space, so you need never see your bags after you arrive. (Cool sibling alert: Capo d'Africa's management have also opened up a suite/townhouse option near the Trevi Fountain.)