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Set in one of Rome’s most desirable locations on the famed Via dei Condotti shopping magnet, this lavish guesthouse is the epitome of luxe. Rooms are fantasias of design and comfort, some with parquet floors and cherubim frescoes on the ceiling, others decked out with wispy fabrics draping plush, canopied beds. Swank amenities include flat-screen TVs, iPod docks, a computer-lending program, Jacuzzi tubs, etc. Note that some rooms are located in the annex building, and these tend to be larger than the ones in the main building. The perfectly manicured rooftop garden provides beautiful views, to be enjoyed at breakfast—where there’s a generous buffet spread—or at sunset, a frosted glass of vino in hand.