By Car
San Francisco is easily accessible by major highways: Interstate 5, from the north, and U.S. 101, which cuts south-north through the peninsula from San Jose and across the Golden Gate Bridge to points north. If you drive from Los Angeles, you can take the longer coastal route (437 miles and 11 hr.) or the inland route (389 miles and 8 hr.). From Mendocino, it's 156 miles and 4 hours; from Sacramento, 88 miles and 1 1/2 hours; from Yosemite, 210 miles and 4 hours.
If you are driving and aren't already a member, it's worth joining the American Automobile Association (AAA; tel. 800/922-8228; www.csaa.com). It charges $49 to $79 per year (with an additional one-time joining fee), depending on where you join, and provides roadside and other services to motorists. Amoco Motor Club (tel. 800/334-3300; www.bpmotorclub.com) is another recommended choice.
By Train
Traveling by train takes a long time and usually costs as much as, or more than, flying. Still, if you want to take a leisurely ride across America, rail may be a good option.
San Francisco-bound Amtrak (tel. 800/872-7245 or 800/USA-RAIL; www.amtrak.com) trains leave from New York and cross the country via Chicago. The journey takes about 3 1/2 days, and seats sell quickly. At this writing, the lowest round-trip fare costs about $300 from New York and $270 from Chicago. Round-trip tickets from Los Angeles range from $120 to as much as $200. Trains arrive in Emeryville, just north of Oakland, and connect with regularly scheduled buses to San Francisco's Ferry Building and the Caltrain station in downtown San Francisco.
Caltrain (tel. 800/660-4287 or 415/546-4461; www.caltrain.com) operates train service between San Francisco and the towns of the peninsula. The city depot is at 700 Fourth St., at Townsend Street.