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37km (23 miles) NE of Arezzo; 15km (9 miles) N of Città di Castello; 122km (76 miles) E of Florence; 240km (149 miles) N of Rome

The medieval walled town of Sansepolcro is another key destination for anyone enamored of the art of Piero della Francesca, the monumentally important painter who was born here around 1412 or 1415. The small village established here around A.D. 1000 was so proud of the bits of the Holy Sepulcher a couple of pilgrims brought back that the town was named Borgo San Sepolcro, long after the alleged relics had been lost. Since then it's also been the birthplace of painters Raffaellino del Colle (1490-1566) and Santi di Tito (1536-1603), and more prosaically, of the Buitoni pasta empire, founded by Giulia Buitoni in 1827.