One of the grandest examples of Spanish Renaissance architecture, this church was designed in 1536 by Diego de Siloé as a family chapel and mausoleum for Francisco de los Cobos, secretary to Carlos V. The richly embellished portal is mere window dressing for the wealth of decoration on the interior of the church, including a sacristy designed by Andrés de Vandelvira with medallions, caryatids, columns shaped like men (atlantes), and coffered decorations and ornamentations. The many sculptures and altarpieces and the spectacular rose windows are also of special interest.