Perched atop a hill overlooking the Verde River, this small, stone-walled pueblo was built by the Sinagua people and was inhabited between 1125 and 1400. The Sinagua, whose name is Spanish for "without water," were traditionally dry-land farmers relying entirely on rainfall to water their crops. When the Hohokam, who had been living in the Verde Valley since A.D. 600, moved on to more fertile land around 1100, the Sinagua moved into this valley. Their buildings progressed from individual homes called pit houses to the type of communal pueblo seen here at Tuzigoot.

An interpretive trail leads through the Tuzigoot ruins, explaining different aspects of Sinaguan life, and inside the visitor center is a small museum displaying many of the artifacts unearthed here. Desert plants, many of which were used by the Sinagua, are identified along the trail.