There are daily flights to Arequipa from Lima and Juliaca on LAN (tel. 01/213-8200; www.lan.com) and from Lima on the much cheaper, newly launched Peruvian Airlines (tel. 01/716-6000; www.peruvianairlines.pe). Flights from Lima and Cusco start at about $109 one-way on LAN; Peruvian Airlines originated its service with offers as low as $59 one-way from Lima.
Aeropuerto Rodríquez Ballón (tel. 054/443-464 or 054/443-458), Av. Aviación s/n, Zamácola, Cerro Colorado, is about 7km (4 1/3 miles) northwest of the city. From the airport to downtown hotels, transportation is by taxi (S/15) or shared colectivo service (about S/5 per person).
The main Terminal Terrestre (tel. 054/427-798), Avenida Andrés Avelino Cáceres, at Av. Arturo Ibáñez s/n, is about 4km (2 1/2 miles) south of downtown Arequipa. Nearby is a newer station, Nuevo Terrapuerto (tel. 054/348-810), Av. Arturo Ibáñez s/n. A huge number of bus companies travel in and out of Peru's second city from across the country, and you'll need to ask if your bus departs from Terminal or Terrapuerto. Taxis are usually present at both stations, though if you had trouble at Terrestre, you'd certainly find one at Terrapuerto; to town it's a 5-minute drive.
From Lima (a 16-hr. ride), recommended companies include Ormeño (tel. 01/472-5000; www.grupo-ormeno.com.pe), Cruz del Sur (tel. 01/311-5050; www.cruzdelsur.com.pe), Civa Transportes (tel. 01/418-1111; www.civa.com.pe), and Oltursa (tel. 01/708-5000; www.oltursa.com.pe). For service from Puno (5 hr.) and Juliaca, contact Cruz del Sur, Civa, or Julsa. Ormeño travels to Arequipa from Puno (as well as Cusco). Other options from Cusco (10-12 hr.) are Civa Transportes and Cruz del Sur. From Chivay/Colca Canyon (3-4 hr.), call Reyna (tel. 054/426-549) or Cristo Rey (tel. 054/213-094).
Note: Arequipa's bus stations -- and especially the buses themselves -- are notorious for attracting thieves. Travelers are advised to pay very close attention to their belongings, even going so far as to lock them to luggage racks. The route between Arequipa and Puno especially has earned a bad reputation. It's best to opt for the more exclusive and safer bus companies recommended above.
Puno-to-Arequipa trains are now available only by private charter for groups of 40 or more, and there are no trains to or from Lima. However, there's always the possibility that the former trajectory might be reinstated at some point in the future (for updates or charters, visit www.perurail.com). The Arequipa rail station is 8 blocks south of the city center, at Av. Tacna y Arica 201 (tel. 054/215-640).
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.