There are no particular safety concerns for women that don't affect men as well. What trouble there might be is nondiscriminatory. What you will find is that you are asked a lot of questions about your marital status and your children, even if you don't have any. Cambodians generally have a fairly conventional view of marriage and children, and if your story diverges from that, they may well be curious. The curiosity is genuine and good-natured, and all explanations will be avidly absorbed. They too will be more than willing to answer your questions about family and children. It is, most certainly, a two-way street.
Dress conservatively, since Cambodia is a conservative country. You should also take a supply of your own tampons. Sanitary pads are the norm for Cambodian women.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.