Hotel Cayo Levisa runs two boats daily to Cayo Levisa leaving from Palma Rubia at 10am and 6pm. The trip takes 30 minutes. It may be possible to hire a boat to take you out if you miss the morning trip, but don't count on it. Return boats from Cayo Levisa leave for Palma Rubia at 9am and 5pm. If you don't have a prearranged tour to the island, the boat ride will run you CUC$10 per person round-trip.
To get to Palma Rubia from Havana by car, drive the northern highway from Mariel to Bahía Honda and continue on for another 40km (25 miles) west to Palma Rubia. If you're coming from Viñales, drive north to La Palma and then another 21km (13 miles) northeast to the embarkation point.
There is no regular or reliable bus service to Palma Rubia or Cayo Levisa. You could hire a taxi from Havana (CUC$75 each way) or take a tour from Viñales or Pinar del Río (CUC$25), but make sure you prearrange a pickup for your return trip if you come by taxi, or you could have trouble getting out of Palma Rubia.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.