Start at Plateia Venizelou, the large clearing at the far curve of the old harbor -- now distinguished by its marble fountain. Head along the east side to see the prominent domed Mosque of Djamissis (or of Hassan Pasha), erected soon after the Turks conquered Chania in 1645. Proceeding around the waterfront toward the new harbor, you'll come to what remains of the great arsenali, where the Venetians made and repaired ships; exhibitions are sometimes held inside. Go to the far end of this inner harbor and you can visit the Minoan ship In any case, you can walk out along the breakwater to the 19th-century lighthouse. Go back to the far corner of the long set of arsenali and Arnoleon, where you turn inland, and then proceed up Daskaloyiannis; on the left, you'll come to Plateia 1821 and the Orthodox Church of St. Nicholas. Begun as a Venetian Catholic monastery, it was converted by the Turks into a mosque -- thus its campanile and minaret! The square is a pleasant place to sit and have a cool drink. Go next to Tsouderon, where you turn right and, passing another minaret, arrive at the back steps of the great municipal market (ca. 1911) -- worth wandering through, although and alas, it has been largely taken over by touristic shops.
If you exit at the opposite end of your entrance, you'll emerge at the edge of the new town. Turn right and proceed along Hadzimikhali Giannari until you come to the top of Halidon, the main tourist-shopping street. The stylish Municipal Art Gallery, at no. 98, sits at the top right side (hours posted). As you continue to make your way down Halidon, you'll pass on the right the famous Skridlof, with its leather workers; the Orthodox Cathedral or the Church of the Three Martyrs, from the 1860s; and on the left the Archaeological Museum .
As you come back to the edge of Plateia Venizelou, turn left one street before the harbor, onto Zambeliou. Proceed along this street; you can then turn left onto any of the side streets and explore the old quarter (now, alas, also overwhelmed by modern tourist enterprises). If you turn up at Kondilaki, follow the signs and turn right at the alley that leads to the Etz Hayyim Synagogue; built in the 17th century (on site of still earlier synagogues) and destroyed in World War II, it has now been beautifully restored and is well worth a visit. Hours have been Monday to Friday 10am to 5pm. Check www.etz-hayyim-hania.org to learn about the history and activities of the synagogue. Back to Zambeliou, continue along, taking a slight detour to Moskhou to view Renieri Gate, from 1608. On Zambeliou again, you'll ascend a bit until you come to Theotokopouli; turn right here and take in the architecture and shops of this Venetian-style street as you make your way down to the sea.
At the end of the street, on the right, the recently restored Church of San Salvatore was converted into a fine little museum of Byzantine and post-Byzantine art (www.culture.gr; irregular hours; admission 2€). After the museum, you'll be just outside the harbor; turn right and pass below the walls of the Firkas, the name given to the fort that was a focal point in Crete's struggle for independence at the turn of the 20th century. The Naval Museum (tel. 28210/26-437) here has some interesting displays and artifacts (daily 10am-4pm; admission 5€); or you can take a seat for welcome refreshment at one of the cafes near the museum entrance.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.