This is ground zero for the amazing revitalization of LoDo. In 1988, the 1888 warehouse was converted into one of the best brewpubs anywhere, and the place has now been pouring first-rate suds and plating up an eclectic menu of inventive pub grub for a quarter-century. Get mac and asiago and cheddar cheese, fish and chips, or buffalo meatloaf, and wash it down with the flagship Railyard Ale or—my favorite—Patty's Chile Beer, sporting a spicy kick. They also make a wide array of small-batch beers, including a zany Rocky Mountain Oyster Stout that debuted in 2012. Then you have the political connections: In 2010, founder John Hickenlooper became the nation's first brewer-governor since Sam Adams left office in Massachusetts in 1797.