Mariscal District (Quito): The 4- to 5-square-block area known as Mariscal, in the heart of Quito's New Town, is chock-full of bars, clubs, discos, and restaurants. It's busy here every night of the week, but especially Thursday through Saturday. Consider starting off on the Plaza Foch with a pub crawl, but be careful and use common sense, because crime against tourists is not unheard of here.
Baños de Agua Santa: As befits a bustling backpacker and adventure-tourist town, Baños has a rocking nightlife. If the rumblings of Volcán Tungurahua keep you up at night here, stroll down Calle Eloy Alfaro, where you'll find a string of bars, clubs, discos, and peñas.
Café Eucalyptus (Cuenca; tel. 07/2849-157): Great tapas, an excellent wine list, locally produced tap beer, and top-notch call liquors combine with a warm and welcoming ambience to make this hands-down the top after-dark gathering spot in Cuenca. I like the couch seating near the fireplace, but the bar is also a good place to settle in. Or, if you're looking for a little more privacy, head to the second floor.
Montañita (South Pacific coast): In addition to their prowess on the sea, surfers are legendary for their après-surf sessions. Montañita is the top surfer town in Ecuador, and its raucous nightlife is fed by the flood of local and international surfers. Lately, they've been pulling out all the stops on the weekend closest to a full moon.
Puerto Ayora (Galápagos): Puerto Ayora has a surprisingly lively, albeit limited, nightlife and bar scene. Bongo Bar (tel. 05/2526-264) is the most happening place in town at night. It's located on a rooftop and opens at 4pm but usually doesn't get busy until after 8pm.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.