SAIS bus lines (tel. 800-211020, from mobiles tel. 199-244141; www.saisautolinee.it) runs an early morning service from Palermo for 9.40€ one way taking 1 3/4 hours; from Catania there are 10 buses a day costing 7.30€ one way and taking 1 hour 20 minutes. Check the website for other locations. Trains (tel. 802021; www.trenitalia.it) stop quite a way down the hill at Enna Bassa, where a bus then whisks you to the historical center, however there are no direct trains from Palermo, so the bus is a much better option. From Catania, the train takes 1 hour 20 minutes and costs 6.10€ one way. If you're driving, take the A19 (Catania-Palermo) autostrada, exiting at Enna.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.