Originally funded by the silkworkers’ guild, the “Nocenti” opened in 1419, and ever since has been one of the world’s most famous childcare institutions. (The Institute still works with UNICEF and others.) Their landmark building was designed by Brunelleschi himself, with elegant Renaissance loggias on the facade and surrounding its interior “Women’s” and “Men’s” courtyards. Inside, a three-floor museum has multimedia exhibits tracing the history of the place and the personal stories of many who benefited from its care. The Institute also has a fine art collection, including Renaissance works by Botticelli and Ghirlandaio displayed in a top-floor gallery, alongside the original painted ceramic roundels by Della Robbia which elegantly completed Brunelleschi’s facade. As you leave, notice the little grated window on the far north wall of the main loggia, where for centuries babies were delivered anonymously to the care of the orphanage.