Tequila is an entertaining (and intoxicating) town, well worth a day trip from Guadalajara. Several taxi drivers charge about 700 pesos to drive you to the town, get you into a tour of a distillery, take you to a restaurant, and haul you back to Guadalajara. A few of them speak English. One recommended driver is José Gabriel Gómez (tel. 33/3649-0791; firstname.lastname@example.org); he has a new car and drives carefully. Call him in the evening. Tour companies also arrange bus trips to Tequila; ask at the ticket kiosk of Tranvías Turísticos, mentioned earlier. That company has started a weekend tour to Tequila, taking people to the Cofradía distillery.
Tequila has many distilleries, including the famous brands Sauza and José Cuervo. All the distilleries -- the big, modern ones and the small, more traditional ones -- offer tours.
Another approach is to take the Tequila Express to the town of Amatitán, home of the Herradura distillery. This excursion is more about having a good time and enjoying some of the things this area is known for than it is about sampling tequila. Serious tequila enthusiasts will be disappointed. There's a nice tour of the distillery, but most of the time is spent watching mariachis and Mexican cowboys perform. The tequila tastings are limited. Everyone has a good time and drinks a fair share, but a trip to the town proper is more informative and offers a greater opportunity for trying different tequilas.
The Tequila Express leaves from the train station on Friday and Saturday, and sometimes on Sunday during vacation and holiday season. It's well organized. You need to be there by 10am. The Guadalajara Chamber of Commerce (Cámara de Comercio), at Vallarta and Niño Obrero (tel. 33/3880-9099), organizes this trip. Buy tickets ahead of time at the main office; at the small office in the Centro Histórico at Morelos 395; at Calle Colón (no phone); or through Ticketmaster (tel. 33/3818-3800). Office hours are Monday through Friday from 9am to 2pm and 4 to 6pm. Tickets cost 980 pesos for adults, 500 pesos for children 6 to 12. The tour includes food and drink. It returns to Guadalajara at about 8pm. Travel time is 1 3/4 hours each way. For more information, see www.tequilaexpress.com.mx.