Guánica, on the Caribbean Sea, lies 73 miles (118km) southwest of San Juan and 21 miles (34km) west of the city of Ponce. The Guánica Dry Forest and adjacent area is a UNESCO-designated world biosphere reserve. The rare bonsai-like forest is home to more than 100 species of migratory and resident birds, the largest number in Puerto Rico. The beach at Guánica is pristine, and the crystal-clear water is ideal for swimming, snorkeling, and diving. Directly offshore is the famed Gilligan's Island, plus six of Puerto Rico's best sites for night or day dives. The area was once known for its leaping bullfrogs. The Spanish conquerors virtually wiped out this species. But the bullfrogs have come back and live in the rolling, scrub-covered hills that surround the 18-acre (7.3-hectare) site of the Copamarina Beach Resort, the area's major hotel.

Guánica is adjacent to the unique Dry Forest and experiences very little rainfall. Nearby mountains get an annual rainfall of 15 feet (4.6m), but Guánica receives only about 15 inches (38 cm). This is the world's largest dry coastal forest region. The upper hills are ideal for hiking. Guánica was once the haunt of the Taíno Indians, and it was the place where Ponce de León first explored Puerto Rico in 1508. One of his descendants later founded the nearby city of Ponce in 1692.

It is also the site of the landing of the Americans in 1898 during the Spanish-American war that began Puerto Rico's century-long relationship with the United States. You reach the harbor by taking the main exit to Guánica from Rte. 116 to Avenida 25 de Julio. A large rock monument on the town's malecón, or harbor, commemorates the landing. The Williams family, descendants of a doctor who arrived with the troops and settled here after marrying a local girl, still live in one of the historic wooden homes along the waterfront. The area has lots of seafood restaurants and bars, as well as snack vendors along a bayside promenade. It is festive on weekend evenings.