John and Dominique de Menil's private collection of fine art is a must-stop for culture hounds in Houston. A total of 17,000 pieces (only a portion is on display at any one time) highlight four major areas: antiquities, Byzantine and Medieval, tribal, and modern art. The main building, designed by acclaimed architect Renzo Piano, is spacious, straightforward, and filled with natural light, fostering an immediate connection between visitors and the works on display. Next door, the Cy Twombly Gallery, also designed by Piano, is particularly captivating. Consider a visit to the nearby Rothko Chapel, an artsy, non-denomination spiritual sanctuary founded by the Menils.