On the one hand, Las Vegas is fairly well equipped for travelers with disabilities, with virtually every hotel having wheelchair-accessible rooms and ramps and other requirements. On the other hand, the distance between hotels (particularly on the Strip) makes a vehicle of some sort virtually mandatory for most people with disabilities, and it may be extremely strenuous and time-consuming to get from place to place (even within a single hotel, because of the crowds). Even if you don't intend to gamble, you still may have to go through the casino, and casinos can be quite difficult to maneuver in, particularly for a guest in a wheelchair. Casinos are usually crowded, and the machines and tables are often arranged close together, with chairs, people, and such blocking easy access. You should also consider that it is often a long trek through larger hotels between the entrance and the room elevators (or, for that matter, anywhere in the hotel), and then add a crowded casino to the equation.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.