Cape Air (tel. 800/352-0714; www.flycapeair.com) flies from San Juan to Mayagüez twice daily (flying time: 40 min.). Round-trip passage starts at $106 per person, and can run as high as $246.
If you rent a car at the San Juan airport and want to drive to Mayagüez, it's fastest and most efficient to take the northern route that combines sections of the newly expanded De Diego Expressway, Rte. 22, with the older Rte. 2. Estimated driving time for a local resident is about 120 minutes, although newcomers usually take about 30 minutes longer. The southern route, which combines the modern Rte. 52 with transit across the outskirts of historic Ponce, and final access into Mayagüez via the southern section of Rte. 2, requires a total of about 3 hours and affords some worthwhile scenery across the island's mountainous interior.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.