Built in 1860 by German Catholics, this is an even more baroque and grand church than its Irish neighbor across the street (St. Alphonsus Church), complete with dozens of life-size saints' statues. The two churches make an interesting contrast to one another. Also inside the church is the national shrine to the hero of the 1867 yellow-fever epidemic, Blessed Father Francis Xavier Seelos, who was beatified (one step away from sainthood) in 2000. See his original coffin, some of his personal belongings, a display containing recently discovered locks of his hair, and the centerpiece of the shrine, a reliquary containing his bodily remains. Should Father Seelos become a saint, expect this shrine to be a big deal and place of pilgrimage.