Panajachel has a fairly active nightlife. For the past 15 years, my favorite place has been the Circus Bar (tel. 502/7762-2056), Avenida Los Arboles, which has a relaxed vibe, simple menu, and decor to match the joint's name. They also frequently have live music. This is also the first place I ever tried Ron Zacapa, Guatemala's world-class 23-year-old aged rum. Circus Bar, just north of Calle Principal, is located in what's considered Panajachel's mini-Zona Viva.
Of the bars on Calle Santander, I like the Maktub'ar Café, which has a relaxed, almost beach-bar feel, and Pana Rock Café (tel. 502/7762-2194), which is a takeoff on the Planet Rock chain.
For a mellow night, La Terraza, Calle Santander (tel. 502/7762-0041), is a second-floor bar and restaurant area with a balcony overlooking Calle Santander.
For loud and late-night dancing, try Sócrates Disco, Calle Principal (tel. 502/7762-1015); El Aleph, Avenida Los Arboles (tel. 502/7762-0192); or El Chapiteau Discoteque, Avenida Los Arboles (tel. 502/7762-0374).
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.