White-water Rafting & Kayaking the Chiriquí and Chiriquí Viejo Rivers: Depending on which section you raft, these two rivers produce serious white-water ranging from technical Class III to Class V, some portions of which are so difficult they've been named "Fear" and "Get Out if You Can." There are plenty of tamer floats on Class II rivers, such as the Esti, for families and beginners. Virtual solitude, beautiful views, and lush surroundings are part of the tour, too.
Zipping through the Treetops on a Canopy Adventure: It's all the rage in Costa Rica, and now Panama has joined in to offer this adrenaline-fueled and exhilarating adventure. Participants climb high to a treetop platform, where they are strapped into a harness and then descend quickly using a pulley attached to a cable. Part of the experience is observing wildlife, mostly birds, from different vantage points in the forest.
Walking to Pirre Mountain: This is a serious jungle trail, located in one of the most remote wildernesses in Central America. Pirre Mountain rises above the Cana Field Station in the Darién National Park. Howler monkeys, spider monkeys, sloths, even snakes are easily and frequently spotted, but just as exciting is the wild sensation that comes from the magnificent jungle surrounding you. At the peak's summit, there is a lookout point with sweeping views.
Surfing Bocas del Toro: There are plenty of surfing hot spots along the Pacific Coast, especially at Santa Catalina, but Bocas is where surfers find everything from beginner-friendly waves to monster, Hawaii-style waves that reach more than 6m (20 ft.). What's special about Bocas, too, is that the water is clear blue, allowing you to see the reef as you race over it, and there are lots of lodging options, restaurants, and thumping nightlife, unlike in Santa Catalina.
Sunbathing in Comarca Kuna Yala: This is the premier beach destination in Panama, with 350 islands scattered off the Caribbean coast that offer picture-postcard beaches with powdery white sand, coral reef, piercing turquoise water, and clusters of swaying palm trees. The colorful Kuna indigenous population administers this province, and their fascinating culture is part of the reason to visit the region, too.
Looking for More Than 500 Species of Birds Along Pipeline Road in Soberanía National Park: This is the "celebrity" bird-watching trail for the immense number of species found here. In fact, for several years Pipeline Road has set the world record for 24-hour bird counts. Even non-birders can't help getting caught up in the action with so many colorful show birds fluttering about, such as mot mots, trogons, toucans, antbirds, colorful tanagers, and flycatchers. The farther you walk or bike along the rainforest trail, the better your chances of spotting rare birds.
Diving around Isla Coiba: This national park only recently opened to the traveling public -- a notorious penal colony that closed here in 2004 kept tourists away, and now the park's virgin waters rate as the best diving site in Panama. Isla Coiba is often described as the Galápagos Islands of Panama, and although the snorkeling is outstanding, diving gets you close to pelagics such as white-tipped sharks, sailfish, turtles, manta rays, dolphins, and so much more. Coiba is home to one of the largest coral reefs in the Pacific Coast of the Americas.
Trekking the Camino Real: Centuries before the Panama Canal, the Spanish built a 80km (50-mile) cobblestone path to transport looted gold from the Pacific to galleons waiting in the Caribbean Sea. You can trace their path, much of which still exists in stone, in about 3 days, beginning with a canoe ride up the Chagres River, an overnight in an Emberá Indian Village, and a tramp through earthy jungle full of birds and wildlife to Nombre de Dios, near Portobelo.
Reeling in a Billfish off the Pacific Coast: Panama's Pacific Coast is legendary for sport fishing, and anglers can battle monster species such as marlin, sailfish, and tuna in the Gulf of Chiriquí and the Gulf of Panama.
Kayaking in the Kuna Yala Comarca: Considering that diving is prohibited in the Kuna Yala, kayaking fills the "sports void," and offers travelers a way to intimately explore the mangrove swamps and the undeveloped beauty of the tiny islands this region is famous for. Along the way, kayakers stop at traditional Kuna communities for cultural tours, land-based hiking, and snorkeling.
Bird-Watching by Dugout Canoe on the Mogue River: The tour outfitter Ancon Expeditions offers a bird-watching and nature adventure near Punta Patiño that takes travelers up the Mogue River in a motorized dugout canoe, winding past dry forest and ancient mangrove swamps for an absolutely authentic jungle experience. From here, it's off to find the harpy eagle, Panama's national bird, and then spend the night with Emberá Indians in one of their rustic communities.