Opened in 2011 in a restored Art Deco mansion that was once the home of Republican-era presidents and a prominent family, Casa Gangotena is the grandest hotel in Quito, if not all of Ecuador. Looking over Plaza San Francisco, one of the city’s largest and most picturesque public squares, the three-story building is loaded with original details. Friezes, mirrors, murals, and tin and hand-painted ceilings fill the property. With its pre-Columbian ceramics, on loan from the nearby Casa del Alabado museum, sparkling crystal chandeliers, glass atria, and gardens bedded with tropical flowers, the property has a uniquely Quiteño sophistication. Subtle modernizations like Osborne & Little wallpaper, intelligent keycards, and black and white Statuarietto marble in the bathrooms allow the hotel to feel updated without changing the story line. The ground floor restaurant, with a ceiling mural by contemporary Ecuadorian artist Lucía Falconí, reinterprets classic Ecuadorian dishes with contemporary plating and market-fresh ingredients. Head up to the wraparound rooftop terrace for the best views of the Old Town and the famed Panecillo Virgin. Service here is topnotch, and the hotel staff is keen on involving guests in one-of-a-kind experiences, such as market tours, chocolate tastings, and in-room cleansings with a local medicine woman.