Downtown San Isidro is just off the Inter-American Highway. A large church fronts the central park, and you’ll find several banks and a host of restaurants, shops, and hotels within a 2-block radius of the park. The main bus station is 2 blocks west of the north end of the central park.
If you’re visiting the San Isidro area in February, head to the nearby Rey Curré village for the Fiesta of the Diablitos, where costumed Boruca Indians perform dances representative of the Spanish conquest of Central America. The 3-day event also fireworks and an Indian handicraft market—this is the best place in Costa Rica to buy hand-carved Boruca masks. The date varies, so it’s best to contact the Costa Rica Tourist Board for more information.