70km (43 miles) NE of Trinidad; 386km (240 miles) E of Havana

Sancti Spíritus lies smack-dab in the middle of the island and is the capital of the province of the same name. Perched on the banks of the Río Yayabo, the old town is a warren of corkscrew streets, many lined with fine, if weathered, colonial homes. Like Trinidad, the town was one of the original seven villas founded by Velázquez in the early 16th century. Today, Sancti Spíritus is a small and not greatly significant, mostly modern provincial capital with an unassuming, lived-in feel. Though much of the city is run-down, it is beginning to renovate some of its more important colonial buildings, including one of the finest house-museums and one of the best-preserved colonial churches in the country, with the hopes of attracting a greater percentage of the travelers that stop off in nearby Trinidad.