From San Salvador, take bus no. 201 to Santa Ana's Metrocentro terminal (at 10a Av. Sur; no phone). The trip takes about 1 hour and 30 minutes, and costs $1 to $1.50.
Buses to and from Metapán leave from Santa Ana's Metrocentro terminal. Bus no. 218 to Tazumal leaves from the corner of 4a Avenidas Sur and 9a Calle Poniente. Lago de Coatepeque can be reached via bus no. 209 from either the Metrocentro terminal or in front of La Universidad Catolica de Occidente. All these buses leave approximately every 20 minutes, and fares start at 35¢.
Simply follow the signs on your 1-hour drive west from San Salvador along the well-paved and well-marked Pan-American Highway, and you'll reach Santa Ana.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.