Nestled in the historic Barrio de Analco, a few blocks from the plaza, this Relais & Chateaux hotel is one of the most plush properties in Santa Fe, which is saying a lot. It's named after the Eastern concept of the five sense—sight, sound, touch, smell, and taste—that must be honored to fully experience life, and the setting stimulates them all. Flower-filled courtyards, bubbling fountains, and artifacts the owners have brought back from Latin America and Central and South Asia create a unique "East meets West" atmosphere that wouldn't be too out of place in Bali or Kashmir. Owner Sylvia Seret's tile mosaics adorn the suites' kitchens and bathrooms, along with kilim rugs and carved teakwood beds. Most accommodations have fireplaces, and some have soaking tubs or steam showers. With all this flair, it's the little touches—personal handwritten notes and weather forecasts, fires laid in the fireplaces every evening—that elevate the service to "best-in-your-life" levels (just ask some of the many repeat guests). Suites on the north side of the street are larger, while less expensive rooms are (unsurprisingly) smaller. The inn boasts the 315 Restaurant and Wine Bar next door, a Tibetan spa treatment room, and wine and cheese every other afternoon.