The Instituto Hondureño de Turismo (Av. Cruz and Calle Mexico; tel. 504/2220-1600; www.letsgohonduras.com; Mon-Fri 7:30am-4:30pm) has friendly English-speaking staff who can provide general information and give you a copy of the excellent bilingual guide, Honduras Tips.
Tegucigalpa is one of the few colonial cities in Central America that does not follow a typical Spanish layout with a grid of streets surrounding a central square, mostly because of the uneven surface of the city. The colonial center of the city is more of a narrow strip on a central grid of about 7 by 20 blocks, and there are several squares -- the largest is Parque Morazán, or the Parque Central. The city's pedestrian-only street, Calle Peatonal, leads west from this square, and other main streets and avenues run into or parallel to it.
Most of the city's museums, churches, and artisan shops can be found within 6 blocks of Parque Central, too. From the center, the majority of the city branches out towards the south and the east. The commercial center and where you will find the best hotels, restaurants, and shops is Colonia Palmira, mostly on the north side of the fast food-lined Boulevard Morazán and in neighboring Colonia San Carlos. West of the Río Choluteca, a river that divides the city, and southwest of the center is the neighborhood of Comayagüela, where most of the city's bus terminals can be found; this is a poorer, less safe part of town.