Thanks to its prime location in a quaint piazza not far from Palazzo Reale, in the heart of the Area Romana, this trattoria might come off as a tourist trap. But Santo Spirito is well loved by locals, especially for its seafood—vast platters of mussels, tuna carpaccio, simply grilled fish, and delicious fettucine served with lobster. Portions are huge, so don’t be tempted to over-order. A high standard of cooking has kept this place thriving since the mid-1970s, even in a city where restaurants open and close every day. This may not be haute cuisine, but it is great home cooking, with fresh ingredients and strong flavors (try the smoked-fish appetizer, the porcini mushroom ravioli, or linguine with squid ink). In summer, tables spread onto the piazza; in winter a cozy fire blazes inside and heaters warm the enclosed patio. Space can be tight, so call ahead for a reservation.