By Train -- The train station is in Piazza Stazione, also called Campo Marzio (tel. 0444-326-707; www.ferroviedellostato.it), at the southern end of Viale Roma. There's frequent service (2-3 per hr.) connecting Vicenza with Venice (52-67 min.), Padua (20 min.), and Verona (30 min.).
By Bus -- The FTV bus station (tel. 0444-223-111; www.ftv.vi.it) is located on Viale Milano, just to the west (left) of the train station. Buses leave frequently for all the major cities in the Veneto and to Milan; prices are comparable to train travel.
By Car -- Vicenza is on Autostrada A4, linking Venice to Milan. Coming from Venice (about 1 hr.), you'll bypass Padua before arriving in Vicenza.
The main tourist information office is at Piazza Matteotti 12 (tel. 0444-320-854; fax 0444-327-072; www.vicenzae.org), next to the Teatro Olimpico. The office is open daily from 9am to 1pm and Monday to Saturday from 2 to 6pm. A second office can be found at Piazza dei Signori 8 (tel. 0444-544-122; fax 0444-325-001), and it is open daily 10am to 2pm and 2:30 to 6:30pm.
The city's layout is quite straightforward and easy to navigate on foot. The train station lies at its southernmost point. From here, head straight ahead on Viale Roma; it ends at a turnabout with gated gardens beyond. Head right (east) into the centro storico, marked by the Piazza Castello, from which the main thoroughfare, the Corso Palladio, starts. Lined with shops, offices, and banks, the arrow-straight Corso cuts through town, running southwest (from Piazza Castello) to northeast (Piazza Matteotti), site of the Teatro Olimpico. Along the Corso you'll find urban palazzi by Palladio and his students; midway, the Piazza dei Signori (and its Basilica Palladiana) will be found on your right (south). Perpendicular to the Corso is the important Contrà Porti, a lovely palazzo-studded street, on your left (north).
There is limited traffic (for taxis, buses, and residents) once you enter the Piazza del Castello and the centro storico. Everything of interest can be easily reached on foot; pick up a map at the tourist office. Even the two villas just outside town can be reached by foot (not suggested in the heat of high season) or bike, as well as by bus or car.