In summer, you can take Wash. 20, the North Cascades Scenic Highway, from I-5 at Burlington. However, in winter this road is closed and it's necessary to cross from north of Seattle on U.S. 2 to Wenatchee and then drive north on U.S. 97 to Wash. 153 at Pateros. If you're coming from north-central or eastern Washington, head east on Wash. 20 at Okanogan.
For more information on the Methow Valley, contact the Winthrop Chamber of Commerce, 202 Hwy. 20 (P.O. Box 39), Winthrop, WA 98862 (tel. 888/463-8469 or 509/996-2125; www.winthropwashington.com), which has its office at Winthrop's main intersection.