Love Chilean wines and would love to visit the wineries there
I haven't done the wineries but I have visited several of them while visiting friends in Santiago. Many offer tasting rooms and some offer tours but I can't really tell you about English language availability as I speak Spanish. The wineries in Chile are, in my opinion, not anywhere near as commercialized as those in California.
Yes you can certainly work in sighseeing inasmuch the Chilean wine country near Santiago is en route to the popular coastal cities of Valparaiso and Viña del Mar. Driving is easy on a well-marked highway, part of which is a modern superhighway toll road.
No, there aren't any mud baths or massages that I recall although I'm sure with some searching you can find a Chilean resort or two that might be what you have in mind.