U.S. 1 is lined with chain hotels in all price ranges. In the Upper Keys, the best moderately priced option is the Key Largo Ramada, off U.S. 1 at MM 100, Key Largo (tel. 800/THE-KEYS or 305/451-3939), which has three pools and a casino boat and is just 3 miles from John Pennekamp Coral Reef State Park. Another good Upper Keys option is Days Inn Oceanfront Resort, U.S. 1 at MM 82.5 (tel. 800/DAYS-INN or 305/664-3681). In the Middle Keys, the Wellesley Inn, 13351 Overseas Hwy., MM 54 in Marathon (tel. 305/743-8550), offers reasonably priced oceanside rooms.
Since the real beauty of the Keys lies mostly beyond the highways, there is no better way to see this area than by boat. So why not stay in a floating hotel? Especially if you're traveling with a group, houseboats can be economical. To rent a houseboat, call Ruth and Michael Sullivan at Smilin' Island Houseboat Rentals, MM 99.5, Key Largo (tel. 305/451-1930). Rates are from $750 to $1,350 for 3 nights. Boats accommodate up to six people.
For land options, consider the recommendations listed.
