1,860km (1,156 miles) NE of Lima

Iquitos, the gateway to the northern Amazon, is Peru's largest jungle town and the capital of its largest department, Loreto, which occupies nearly a third of the national territory and is nearly the size of Germany. You must fly to get here -- unless you have a week to kill for hot and uncomfortable river travel -- but the pockets of jungle down- and upriver from Iquitos are among the most accessible of the Peruvian Amazon basin. Some of the best jungle lodges in the country, some of which are well into their fifth decade of ecotourism, are located just a few hours by boat from Iquitos. Because the region is the most trafficked and developed of the Peruvian Amazon, costs are lower for most jungle excursions than they are in the more exclusive Manu Biosphere Reserve in southeastern Peru.

The most important port city of the Amazon lies at the confluence of the Nanay and Itaya rivers. The city was founded in 1754 by Jesuit missionaries, although some continue to claim that it actually was not founded until nearly a century later. The city's proximity to South America's greatest rainforest and its isolation from the rest of Peru have created a unique tropical atmosphere. In the late 1860s and 1870s, pioneering merchants got rich off the booming rubber trade and built ostentatious mansions lined with glazed tiles along the river. Iquitos rivaled Manaus in Brazil for leadership of the rubber trade. The city went from boom to bust, although oil exploration, shipping, logging, and other export trade later revived and sustained the city's fortunes. Today tourism is quite evidently among Iquitos's most important industries.

Iquitos is far from the grand port of old. The modern city of nearly a half-million is composed of descendants of original ethnic groups such as the Yaguas, Boras, Kukama, and Iquitos, as well as significant populations of immigrant groups from Europe and Asia. Those great homes along the malecón are now faded monuments to the city's glory days, and just blocks from the main square lies the fascinating Belén district, where families live in a squalid pile of ramshackle wooden houses on the banks of the river. Some are propped up by spindly stilts, while others float, tethered to poles, when the river rises 6m (20 ft.) or more.

The Belén district looks distinctly Far Eastern, and Iquitos has more in common with steamy tropical Asian cities than the highlands of Peru. Like a South American Saigon, the air is waterlogged and the streets buzz with unrelenting waves of motorcycles and motocarros. Locals speak a languid, mellifluous Spanish unmatched in other parts of the country, and pretty prostitutes loll about the Plaza de Armas. Locals dress not in alpaca sweaters and shawls, but in flesh-baring tank tops and short skirts.

Iquitos has a relaxed, intoxicating feel that's likely to detain you for a couple of days at least. But for most visitors, the lure of the Amazon rainforest is the primary attraction. Virgin rainforest, though, is hard to find. To lay eyes on exotic wildlife, such as pink dolphins, caimans, and macaws, you have to get far away from Iquitos, at least 80km (50 miles) out and onto secondary waterways. Options for rainforest excursions include lodge visits, river cruises, and, for the adventurous, independent guided treks.