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With sister restaurants in Miami and Bogotá, the Cielo triumvirate is often hailed among Latin America’s best restaurants. Here in Medellín, superstar chef Juan Manuel Barrientos brings molecular gastronomy to a captivated local and international crowd. The freshest local ingredients combined with indigenous techniques and a dash of science result in an epic dining experience. Allow 4 hours for the fixed 12- or 15-course tasting menu (or “moments”). There are rose petals to cleanse your hands, an Amazonian “tree of life” made from cassava, chicken marinated in mustard seeds and beer, liquid nitrogen citrus sorbet, and chocolate truffles sprinkled with gold dust. The elegant but exotic dining room provides a serene backdrop for a culinary odyssey (which in NYC, Paris, or London, would be at least five times the price).