Paso Robles is on U.S. 101; there's an exit for the town's main thoroughfare, Spring Street. Hwy. 46 intersects, and briefly joins, U.S. 101. Amtrak (tel. 800/USA-RAIL [872-7245]; www.amtrak.com) offers daily service to Paso Robles from Oakland and Los Angeles.
Many wineries are on the winding roads off Hwy. 46 on either side -- try to cluster your visit according to this destination, visiting one side and then the other. You'll be able to feel how the weather on the western side, which is cooler due to higher elevations and frequent coastal fog, differs from the hotter east side, on a flat plain leading inland; winemakers bicker constantly over which conditions are better for growing wine grapes.
For a list of area wineries, tasting rooms, and seasonal events, contact the Paso Robles Vintners and Growers Association, 744 Oak St., Paso Robles, CA 93446 (tel. 800/549-9463 or 805/239-8463; www.pasowine.com). Additional information on the area is offered by the Paso Robles Chamber of Commerce and Visitors & Conference Bureau, 1225 Park St., Paso Robles, CA 93446 (tel. 800/406-4040 or 805/238-0506; www.pasorobleschamber.com).