Don’t be fooled by the modest 18th-century exterior; the 14th-century chapel inside contains a real treasure. Before young Raphael Sanzio made a name for himself in Florence and Rome, he settled briefly in Perugia, where in 1504 he painted the first of the many frescoes that would make him famous in his own lifetime (not to mention vaulting him into the triumvirate of great Renaissance masters, with Da Vinci and Michelangelo). Unfortunately only the upper half of his “Holy Trinity” remains here, and that is damaged. The work seems touchingly modest compared to the complex “School of Athens” and other works he later did for the Vatican. As energetic in life as he was in his work, Raphael ran a huge workshop, had dozens of patrons, was in line to be a cardinal, and died on his 37th birthday, allegedly after a lustful session with his mistress. After Raphael’s death, his then-septuagenarian teacher, Perugino, painted the six saints along the bottom of the fresco.