Opened to commemorate the 500th anniversary of the city’s founding, this museum traces the history of Ponce back to its roots in the days of the Taíno. There are exhibits on ecology, architecture, the economy, medicine, politics, and the people of Ponce. It’s housed in the Casa Salazar, an eye-poppingly lovely example of the city’s turn-of-the-20th-century style, which mixed neoclassic and Moorish details such as pressed-tin, mosaic tile, and stained glass.