A good option is the Hotel Fernandina (tel. 05/2526-499; www.hotelfernandina.com.ec), located 1 block inland from Avenida Charles Darwin, but right downtown.
You might also check out La Peregrina (tel. 05/2526-323), a small B&B about midway along Avenida Charles Darwin.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.