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The closest thing to a boutique hotel in the Florida Keys is the brainchild of a trio of New York women who used to work for hip hotelier Ian Schrager. The 16-suite Casa Morada is tucked off a sleepy lane, radiating serenity and style in an area where serenity abounds, but style not so much (decor is decidedly island, but think Cabo cool rather than Gilligan’s). Sitting on 1 3/4 acres of prime bayfront, it features a limestone grotto, freshwater pool, and poolside drinks service. Each of the cool rooms has either a private garden or a terrace; request the one with the open-air Jacuzzi facing the bay. There’s no restaurant, though a breakfast is included daily. Enjoy free use of bikes, paddleboards, snorkel equipment, bocce pitch, and morning yoga.