Flying from San Juan to Ponce five times a day, Cape Air (tel. 800/352-0714; www.flycapeair.com), a small regional carrier, offers flights for $154 round-trip. Flight time is 25 minutes.
If you're driving, take Las Américas Expressway south to the Luis A. Ferré Expressway Hwy. 52, then continue south. Once you pass over the central mountain range and reach the south coast, you will continue west until Ponce. The trip takes about 1 1/2 hours.
Note: This information was accurate when it was published, but can change without notice. Please be sure to confirm all rates and details directly with the companies in question before planning your trip.