Flying from San Juan to Ponce five times a day, Cape Air (tel. 800/352-0714; www.flycapeair.com), a small regional carrier, offers flights for $154 round-trip. Flight time is 25 minutes.
If you're driving, take Las Américas Expressway south to the Luis A. Ferré Expressway Hwy. 52, then continue south. Once you pass over the central mountain range and reach the south coast, you will continue west until Ponce. The trip takes about 1 1/2 hours.