There are 13 buses per day to and from Madrid (trip time: 3 1/2-4 1/2 hr.). There are also five buses running daily from Cáceres (45 min.), and six from Badajoz (2 hr.). A one-way ticket from Madrid costs 16€ to 27€; from Cáceres, 3€; and from Badajoz, 10€ to 18€. Trujillo's bus station, Calle Marqués Albayda (tel. 92-732-12-02; www.avanzabus.com), is on the south side of town, on a side street that intersects with Calle de la Encarnación.
Trujillo lies at a network of large and small roads connecting it to Cáceres via the N-521 and to Lisbon and Madrid via the N-V superhighway. Driving time from Madrid is around 4 hours.
The tourist office, on Plaza Mayor (tel. 92-732-26-77; www.ayto-trujillo.com), is open daily 10am to 2pm and 4 to 7pm.