You can choose to stay on the mainland or on the beach. As you might expect, the beachfront accommodations are a bit more expensive -- but, I think, worth it. A great spot to know, especially if you're planning to fish, is the Key West Inn at Captain Hiram's, 1580 U.S. Hwy. 1, Sebastian (tel. 772/388-8588; www.hirams.com), where 70 rooms are available adjacent to the restaurant and overlooking the water.
Comfortable and inexpensive chain options near the Horizon Outlet Center, off S.R. 60, include Holiday Inn Express (tel. 800/465-4329 or 772/567-2500) and Hampton Inn (tel. 800/426-7866 or 772/770-4299). Rates for both run between $99 and $120, and include breakfast and local calls.
Camping -- The Vero Beach and Sebastian areas of the Treasure Coast are popular with campers, who choose from nearly a dozen camping locations. If you aren't camping at the scenic and popular Sebastian Inlet State Park, try the Vero Beach RV Park, 8850 U.S. 1, Wabasso (tel. 772/589-5665). This 120-site campground is 2 miles from the ocean and the Intracoastal Waterway, and a quarter-mile from the Indian River, a big draw for fishing fanatics. There's access to running water and electricity, as well as showers, a shop, and hookups for RVs. Rates are $46 per site and $29 for tents. To get here, take I-95 to exit 69 East; at U.S. 1, turn left.