St. Thomas has more nightlife than any other island in the U.S. or British Virgin Islands, but it's not as extensive as you might think. Charlotte Amalie is no longer the swinging town it used to be. Many of the streets are dangerous after dark, so visitors have stopped visiting the area for nightlife, with the exception of a few places, such as the Greenhouse. Much of the action has shifted to Frenchtown, which has some great restaurants and bars. However, just as in Charlotte Amalie, some of these little hot spots are along dark, badly lit roads. The primary problem here is mugging, although some of the criminal activity appears to be drug-related. Sexual assault is known to occur, but happens rather infrequently.
The big hotels, such as Frenchman's Reef & Morning Star Marriott Beach Resort, Bolongo Bay, or the Ritz, have the most lively after-dark scenes. After a day of sightseeing and shopping in the hot West Indies sun, sometimes your best bet is just to stay at your hotel in the evening, perhaps listening to a local fungi band playing traditional music on homemade instruments.
Unwanted Attention -- Sexual harassment can be a problem in certain bars in Charlotte Amalie. Any of the major resort hotels are generally safer, and any place we've recommended can be viewed as hospitable (though, of course, creeps can be found in any bar).
Gay & Lesbian Nightlife -- St. Thomas might be the most cosmopolitan of the Virgin Islands, but it is no longer the "gay paradise" it was in the 1960s and 1970s. The major gay scene in the U.S. Virgins is now on St. Croix. That doesn't mean that gay men and lesbians aren't drawn to St. Thomas. They are, but many attend predominantly straight establishments, such as the Greenhouse.